For an oocyte being Completely ready for fertilization and expansion into an embryo, the right list of genes needs to be turned on. Namekawa suspected that this pre-programming on the oocyte genome occurs in numerous levels — the main one particular starting round the time a woman is born. He thought that chromatin remodeling proteins did Significantly of the operate, by shifting spools all around.
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“If we understand how this chromatin state is established, And just how it pertains to oocyte high quality, it could finally bring on therapies for a few forms of infertility,” claims Namekawa.
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